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USA
Personne àcontacter Mr. Prime
155 Federal Street, Suite 700, Boston, Massachusetts
Membrane proteins are specialized proteins located on the cell
membrane, playing a critical role in various biological processes
such as material transport, signal transduction, energy conversion,
and intercellular communication. Membrane proteomics studies the
structure, function, interactions, and variations of membrane
proteins across diverse biological processes. The hydrophobic lipid
bilayer embedding these proteins makes traditional water-soluble
protein separation and purification methods ineffective, leading to
challenges in extracting and purifying membrane proteins.
Furthermore, their structural diversity and complexity complicate
identification and characterization. However, with advances in mass
spectrometry, bioinformatics, and other technologies, these
challenges are gradually being addressed.
MtoZ Biolabs employs Thermo Fisher's Orbitrap Exploris **0 mass
spectrometer platform combined with Nano-LC chromatography to
provide comprehensive subcellular proteomics analysis services,
including qualitative and quantitative analysis of cellular,
mitochondrial, and chloroplast membrane proteomes.
Analysis Workflow
1. Membrane Protein Isolation and Enrichment
After cell or tissue disruption, the cell membrane or subcellular
structures are isolated by centrifugation and other methods, and
membrane proteins are extracted for further purification.
2. Protein Digestion
Various proteases digest membrane proteins into smaller peptide
fragments for subsequent mass spectrometry analysis.
3. Peptide Separation
The digested peptides undergo further purification via HPLC.
4. Mass Spectrometry Analysis
The purified peptides are analyzed using mass spectrometry,
recording mass spectrometry data like peptide ion mass-to-charge
ratios.
5. Mass Spectrometry Data Analysis
The collected mass spectrometry data are cross-referenced with
protein databases to identify and quantify membrane proteins.
6. Bioinformatics Analysis
Comprehensive analysis of the protein data, including protein
classification, functional prediction, pathway analysis, and
subcellular localization.
Service Advantages
1. High-throughput, High-resolution Identification of Membrane
Proteins, Including Low-abundance Membrane Proteins
2. Multi-dimensional, Multi-layered Technology to Study Membrane
Proteins, Providing Comprehensive Membrane Proteome Data
3. Integrates with other Omics Technologies like Transcriptomics
and Metabolomics to Explore Membrane Protein Functions and
Mechanisms From a Systems Biology Perspective
Deliverables
In the technical report, MtoZ Biolabs will provide you a detailed
technical information, including:
1. Experimental Procedures
2. Relevant Mass Spectrometry Parameters
3. Detailed Information on Membrane Proteomics Analysis
4. Mass Spectrometry Images
5. Raw Data
About Us
MtoZ Biolabs is an integrate contract
research organization (CRO) providing advanced proteomics,
metabolomics, bioinformatics, and biopharmaceutical analysis
services to researchers in biochemistry, biotechnology, and
biopharmaceutical fields. The name of MtoZ represents mass to
charge ratio in mass spectrometry analysis, as most of our services
are provided based on our well-established mass spectrometry
platforms. Our services allow for the rapid and efficient
development of research projects, including protein analysis,
proteomics, and metabolomics programs.
MtoZ Biolabs is specialized in quantitative
multiplexed proteomics and metabolomics applications through the
establishment of state-of-the-art mass spectrometry platforms,
coupled with high-performance liquid chromatography technology. We
are committed to developing efficient, and effective tools for
addressing core bioinformatics problems. With a continuing focus on
quality, MtoZ Biolabs is well equipped to help you with your needs
in proteomics, metabolomics, bioinformatics, and biopharmaceutical
research. Our ultimate aim is to provide more rapid,
high-throughput, and cost-effective analysis, with exceptional data
quality and minimal sample.​
| Pays: | USA |
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| Prix FOB: | Obtenir le dernier prix |
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