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USA
Personne àcontacter Mr. Prime
155 Federal Street, Suite 700, Boston, Massachusetts
Proteomics is a scientific field that studies the composition,
structure, function, and interactions of all proteins in an
organism. Its goal is to establish a comprehensive protein
information library and understand their roles in life. However,
the proteins whose biological functions have been thoroughly
studied are still few, and some protein-coding genes still lack
relevant annotations. Nonsynonymous single nucleotide
polymorphisms, a large variety of proteins produced by alternative
splicing and post-translational modifications of proteins, make
gene annotation more difficult. The emergence of high-throughput
gene knockout technology provides a powerful tool for the detection
of large-scale protein and their forms. High-throughput gene
knockout technology can be used to silence or knockout specific
genes to observe changes in the proteome. Combined with
high-resolution mass spectrometry, it can be used to analyze
protein composition, modifications, and relative abundance.
The combination of high-throughput gene knockout technology and
proteomics provides a new perspective for biological research. By
combining these two technologies, researchers can study the impact
of specific gene knockouts on the proteome, and identify proteins
associated with the knocked-out genes, which help better understand
the interactions between genes and proteins, and reveal protein
regulatory networks. For example, researchers can determine how the
knockout of a specific gene affects protein expression in cancer
cells to discover new cancer treatment methods. Furthermore, this
combination can also be used to study the mechanisms of various
diseases such as neurodegenerative disease, immune disease, and
metabolic disorder.
MtoZ Biolabs, based on the high-resolution proteomics analysis
platform combined with high-throughput gene knockout technology,
can provide you with a comprehensive solution from gene knockout to
proteomics analysis. Our advanced CRISPR/Cas9 system can achieve
single/multiple gene knockouts of human/mouse cell lines, primary
cells, immune cells, and iPS cells, frameshift mutations, and large
sequence deletions. When KO cells obtained, they are cultured and
the proteins expressed by them are extracted. Using a
high-resolution mass spectrometry platform for their proteomics
analysis, the specific role of the knocked-out gene at the protein
level is elucidated, revealing the mechanism how genes regulate
proteins. MtoZ Biolabs aims to provide you with the highest quality
scientific research service. We look forward to cooperating with
you. Welcome to contact to learn more about our service.
Service Advantages
1. High Knockout Efficiency
Optimized CRISPR/Cas9 system with over *0% target knockout
efficiency at *0%; after gene knockout, we use Sanger sequencing
and in-depth proteomics technology to doubly verify the knockout
efficiency to ensure the accuracy of the data.
2. Comprehensive Proteomics Analysis Platform
Our proteomics analysis platform is equipped with comprehensive
sample pre-treatment instruments, high-specificity protein
modification enrichment platform, ultra-high-performance liquid
chromatography coupled with high-resolution mass spectrometry, and
protein N-terminal sequence analyzer, which can achieve efficient
protein extraction at the omics level, high-efficiency enrichment
of specific modified peptides, and protein identification, relative
quantification (3D & 4D), and absolute quantification analysis,
and comprehensive analysis of the proteome expressed by KO
cells.
3. Short Project Cycle
Before performing the gene knockout experiment, we analyze the
necessity and expression level of genes in different cells to
ensure the feasibility of the experiment and reduce the risk of
experiment failure; there is no need for gRNA validation to the
pre-experiments of customers' targets, significantly shortening the
project cycle.
4. One-Stop Service
MtoZ Biolabs has much experience in omics service and professional
technicians who can customize the optimal project plan fitting your
needs. You only need to tell us your experimental purpose and send
your samples. MtoZ Biolabs will take care of all subsequent project
steps, including sample processing, experimental analysis, data
analysis, and project report.
Applications
1. Disease Mechanism Research
By knocking out specific genes, researchers can observe changes in
expression and regulation of protein under pathological conditions.
For example, in cancer research, by knocking out genes associated
with cancer development, researchers can better understand the
biological mechanisms of tumors.
2. Drug Target Discovery
By analyzing the impact of gene knockouts on the proteome, new drug
targets can be identified. For example, in the search for new drugs
to treat Alzheimer's disease, researchers can find potential
therapeutic targets by knocking out genes associated with cognitive
decline.
3. Functional Genomics Research
The combination of gene knockout technology with proteomics can
study the functions of genes and proteins in cells and how they
mutually interact to regulate biological processe.
4. Systems Biology
In systems biology, the combination of gene knockout technology
with proteomics can build protein-protein interaction networks,
helping to understand complex biological systems. For example,
researchers can reveal key regulatory networks in pathological
process by analyzing protein changes.
About Us
MtoZ Biolabs is an integrate contract research
organization (CRO) providing advanced proteomics, metabolomics,
bioinformatics, and biopharmaceutical analysis services to
researchers in biochemistry, biotechnology, and biopharmaceutical
fields. The name of MtoZ represents mass to charge ratio in mass
spectrometry analysis, as most of our services are provided based
on our well-established mass spectrometry platforms. Our services
allow for the rapid and efficient development of research projects,
including protein analysis, proteomics, and metabolomics
programs.
MtoZ Biolabs is specialized in quantitative
multiplexed proteomics and metabolomics applications through the
establishment of state-of-the-art mass spectrometry platforms,
coupled with high-performance liquid chromatography technology. We
are committed to developing efficient, and effective tools for
addressing core bioinformatics problems. With a continuing focus on
quality, MtoZ Biolabs is well equipped to help you with your needs
in proteomics, metabolomics, bioinformatics, and biopharmaceutical
research. Our ultimate aim is to provide more rapid,
high-throughput, and cost-effective analysis, with exceptional data
quality and minimal sample.​
| Pays: | USA |
| N ° de modèle: | - |
| Prix FOB: | Obtenir le dernier prix |
| Localité: | - |
| Prix de commande minimale: | - |
| Commande minimale: | - |
| Packaging Detail: | - |
| Heure de livraison: | - |
| Capacité de Fournir: | - |
| Payment Type: | - |
| Groupe de produits : | - |
