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Business Address:C8-2, Optics Valley United Technology City, Huarong District, Ezhou, Hubei
TIGIT (T cell Immunoreceptor with Ig and ITIM domains)
TIGIT (T cell Immunoreceptor with Ig and ITIM domains), also known
as Vstm3, Vsig9, WUCAM, is a newly discovered co-stimulatory
molecule with an immunosuppressive effect with a molecular weight
of ****4kD in recent years, in T cells and NK cells Expressed
above, it has an immunoglobulin-like domain, a transmembrane
domain, and an immunoglobulin tyrosine inhibitory motif (ITIM),
hence the name TIGIT. TIGIT is a type I transmembrane protein and
belongs to the CD*8 member of the Ig superfamily. Human TIGIT has
**4 amino acids, including a signal peptide of *1aa, an
extracellular region of **0aa (containing a V-type
immunoglobulin-like domain and two potential N-terminal
glycosylation sites), a transmembrane region of *1aa, and carrying
*2aa cytoplasmic region of ITIM motif.
TIGIT, an inhibitory receptor shared by emerging NK and T cells,
has high affinity with PVR (CD**5), which is highly expressed in
tumor cells, and directly inhibits the killing effect of NK and T
cells on tumor cells through the ITIM region of TIGIT Inhibition of
CTLA*4 on T cells.
TIGIT-his and TIGIT-Fc expressed by the mammalian cells of the
company have high purity and good activity.
Human TIGIT (His tag)Â Â Â Â Â Â
   TIGIT (Fc tag)
Expression host: HEK**3Â Â Â Â Â Â
  Expression host: HEK**3
Molecular weight: ****3 kDÂ Â Â Â Â Â
 Molecular weight: ****5 kD
Concentration: **2mg / ml     Â
  Concentration: **2mg / ml
Purity:> *0%Â Â Â Â Â Â Â
      Purity:> *0%
Storage environment: 1 × PBS (pH7.4)   Storage
environment: 1 × PBS (pH7.4)
Storage conditions: short-term storage at 4℃, long-term storage
at **0℃. Avoid repeated freezing and thawing.
Safety Tips: Not for human experiment
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| Groupe de produits : | In Vitro Diagnostic Kit Raw Materials |
