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| Catalog Number:Â Â ****7 |
| Gene Symbol:Â Â EGFR/HER1/ERBB1 |
| Description: Â Â Anti-EGFR (L***-P**3) S Mouse Monoclonal Antibody |
| Background: Â Â EGFR is a receptor tyrosine kinase binding ligands of the EGF family and activating several signaling cascades to convert extracellular cues into appropriate cellular responses. It activates at least 4 major downstream signaling cascades including the RAS-RAF-MEK-ERK, PI3 kinase-AKT, PLCgamma-PKC and STATs modules. Defects in EGFR are associated with lung cancer (LNCR). |
| Immunogen: Â Â A synthetic peptide from the internal region of EGFR which includes the mutation of (L***-P**3) S, human origin. |
| Applications: Â Â ELISA, WB, IF, IHC |
|
Recommended Dilutions: Â Â ELISA: 1:*****1:***0Â WB: 1:****1:***0Â IHC: 1:***1:**0 |
| Concentration: Â Â 1 mg/ml |
| Host: Â Â Mouse |
| Format: Â Â Liquid |
| Clonality: Â Â Monoclonal |
| Isotype: Â Â |
| Purity: Â Â Purified from ascites |
| Storage buffer: |
| Preservative:Â Â no |
| Constituents:Â Â PBS (without Mg2+ and Ca2+), pH 7.4, **0 mM NaCl, *0% glycerol |
| Species Reactivity:Â Â Recognizes EGFR (L***-P**3) S, but not wild type EGFR protein from vertebrates. |
| Storage Conditions:   Store at **0°C. Avoid freeze / thaw cycles |
