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Synephrine (or oxedrine) is a drug commonly used for weight loss. While its effectiveness is widely debated, synephrine has gained significant popularity as an alternative to ephedrine, a related substance which has been made illegal or restricted in many countries due to health risks and its use as a precursor in the illicit manufacturing of methamphetamine. Products containing bitter orange or synephrine are suspected of causing adverse cardiovascular reactions [1]. Synephrine is derived primarily from the fruit of Citrus aurantium, a relatively small citrus tree, of which several of its more common names include Bitter Orange, Sour Orange, and Zhi shi. Dietary supplements generally supply single oral doses of 3–*0 mg, while as a pharmaceutical agent it is given orally or by parenteral injection in *0–**0 mg doses as a vasoconstrictor to hypotensive patients.[2] Synephrine HCLSynephrineHydrochlorideCharacter: Off-white powder Molecular formula: C9H*3NO2.HCL Molecular weight: **3.*7 CAS No.: ********4 Specification: Items Specification Assay ≥*5% Melting point **0~**0°C Loos on drying ≤1.0% Heavy metals(ppm) ≤*0 As(ppm) ≤1 Total Plate Count <***0CFU/g ***** negative Salmonella negative Yeast
