Prix FOB
Obtenir le dernier prix1 ~ 400 / Kilogram ( Negotiable )
|1 Gram Minimum Order
Pays:
China
N ° de modèle:
Alpha GPC 99%
Prix FOB:
1 ~ 400 / Kilogram ( Negotiable )Obtenir le dernier prix
Localité:
China
Prix de commande minimale:
1 per Kilogram
Commande minimale:
1 Gram
Packaging Detail:
25kg/drum
Heure de livraison:
15 days after payment
Capacité de Fournir:
30 Metric Ton per Month
Payment Type:
T/T, L/C, Western Union
Groupe de produits :
China
Personne àcontacter Ms. Jennifer
No.100 Jinxi Road, Wuxi, Jiangsu
  Choline Alfoscerate
Brain anti-aging
nutrition
Brain health food
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Choline Alfoscerate powder
Formula: C8H*0NO6P
MW: **7
Appearance: White to light yellow fine
powder
Purity: *9% min
Packing: 5kg/foil bag; *5kg/drum
Store: Keep away from fire and heat source; hermetically
deposit; keep in shady, cool and dry condition; protect against
the tide.
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Choline Alfoscerate Liquid
Properties: colorless
transparent liquid. Soluble in water and organic solvents.
Molecular formula: C8H*0NO6P
Choline Alfoscerate (GPC) L-alfa-glycerylphosphorylcholine
L-alfa-GPC
CAS No. :*********9
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Choline
alfoscerate (also known as Alpha-GPC) is L-a-glyceryl
phosphorylcholine (GPC),a key brain cell membrane phospholipid
and cholinergic precursor. It is a source of choline for the
synthesis of the neurotransmitter acetylcholine, with a greater
ability to penetrate the blood-brain barrier than conventional
choline sources.
More
importantly, Choline alfoscerate has been experimentally
demonstrated to reduce or reverse agerelated structural changes
in the frontal cortex and hippocampus andinducedfunctional
deficiencies of the cholinergic system. Research supports choline
alfoscerate's ability to support healthy brain function and the
release of somatotrophin (hGH).
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Main
Applications of Choline alfoscerate
:
As
reported by literature:
Support
in Alzheimer’s disease.
Cognitive
support.
Infant
brain development.
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Choline alfoscerate (al-FOSS-er-ate), or alpha-glycerylphosphorylcholine (GPC), is a phospholipid - a complex fatty substance containing phosphorus, like phosphatidylserine and phosphatidylcholine - and is an important building block in the construction ofnerve cell membranes. After completing an analysis of thirteen published clinical trials, involving over ***0 patients, a group of Italian scientists concluded that "The stated therapeutic usefulness of Choline Alfoscerate in the relief of cognitive symptoms, such as memory and attention impairment, differentiates [it] from cholinergic precursors used in former clinical trials", such as choline, lecithin, or phosphatidylcholine. The reason, as evidence now suggests, is that the effects of this versatile nutrient extend well beyond its role as a mere choline source: choline alfoscerate supports the restoration of a whole spectrum of youthful cholinergic functions.
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Weak Link
1: Decreased Choline Uptake
Choline
alfoscerate is a rapidly absorbed source of choline, which easily
enters the brain. GPC raises free plasma choline more rapidly
than other uncharged choline precursors. Because it is a
phospholipid - the same sort of material of which the brain and
Blood-Brain Barrier (BBB) are made -Choline Alfoscerate does not
carry the electrical charge of regular choline, and so freely
crosses the blood-brain barrier. The choline from Choline
Alfoscerate is
incorporatedinto brain phospholipids within *4 hours of absorption.
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Weak Link
2: Enzyme Imbalances
The
brain makes acetylcholine using an enzyme known as choline
acetyltransferase. As we get older, ChAT activity goes down,
while the activity of enzymes that break down chat goes up. As a
result, aging brains make less acetylcholine from the choline
available to them, while they tear acetylcholine down more
quickly. Animal studies suggest that Choline Alfoscerate may also
improve the levels of ChAT.
Weak
Link 3: Brain Drain
This
is perhaps the most serious issue facing the aging brain: the
cholinergic neurons of the brain simply wither away with age. The
number of neurons declines, and those neurons that remain
literally shrink, becoming less well-connected to the rest of the
brain. This decay is made all the worse by the fact that the
ability of the surviving cholinergic neurons to release and
respond to ACh is also impaired with age!
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Even more
incredibly, animal studies show that Choline Alfoscerate actually
increases the number of cholinergic neurons as well. In addition,
Choline Alfoscerate may reverse the atrophy of existing
cholinergic neurons, since studies show that Choline Alfoscerate
increases the number of receptors for nerve growth factor (NGF).
Supplying NGF to old monkeys clearly reverses cholinergic neuron
atrophy, restoring the number and size of these neurons to more
youthful levels.
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Controlled
Trials: It Works
In
one controlled trial in victims of vascular dementia, greater
improvements on several measures of cognitive function were seen
amongst those patients treated with Choline Alfoscerate than in
those given another choline precursor. The differences were
statistically significant, and both patients and physicians rated
the results with GPC more satisfactory.
Another
controlled trial in Alzheimer's disease compared Choline
Alfoscerate to acetyl-L-carnitine (ALCAR), a nutrient already
proven to slow the progression of AD in younger patients. Most
behavioral and mental function test results showed improvement in
the Choline Alfoscerate group - and the improvements were greater
than those seen in the ALCAR group.
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There is
also a hint that Choline Alfoscerate may prove of use in
Parkinson's disease (PD). PD is characterized by reductions in
the production of the neurotransmitter dopamine in an area of the
brain called the substantia nigra. This leads to a loss of motor
control, typically manifesting in facial ticks or tremors, dry
mouth, and a "masklike" facial expression. In laboratory animals,
measures of dopaminergic activity were enhanced by GPC
treatment.
Choline alfoscerate, or L-Alpha Glycerylphosphorylcholine (Alpha GPC), occurs naturally in the fatty acids of soy plants. It is considered important to the synthesis of acetylcholine, a neurotransmitter that supports brain health and the production ofhuman growth hormone(HGH). As the brain ages, acetylcholine levels typically decrease, which can lead to cognitive disorders such asdementia and Alzheimer's. Studies suggest that choline alfoscerate can treat Alzheimer's and other forms of age-related cognitive decline. Evidence also suggests that this type of choline may be able to stimulate increased blood levels of human growth hormone in the elderly, for a healthier, more youthful body.
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Alpha-GPC is marketed in the United States as adietary supplement. Prescription forms ofcholine alfoscerate are administered in Europe to treat Alzheimer's disease. Dementia, stroke, and transient ischemic attack (TIA) patients may also benefit from alpha GPC use. Alpha-GPC is marketed as a dietary supplement that can enhance memory, cognitive ability and learning ability.
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Unlike some other forms of choline, choline alfoscerate normally penetrates the blood-brain barrier easily. Once it has crossed the blood-brain barrier, the brain makes acetylcholine from alpha-GPC. Acetylcholine is an important neurotransmitter that is believed responsible for memory, learning, normal cognitive function and human growth hormone production.
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As the brain ages, its neurons and neural receptors can atrophy, ceasing to function. Aging brains often experience significant declines in the function of memory-specific neural receptors. Choline alfoscerate may help to stimulate the growth of new neurons and neural receptors, and may help reverse the neural atrophy that can cause loss of cognitive function. As a result, alpha-GPC may be able to slow, stop, or reverse cognitive decline in those already suffering from Alzheimer's, dementia or other forms of age-related cognitive decline. It is hoped that choline alfoscerate may prove invaluable to the treatment of Alzheimer's, dementia and other age-related cognitive disorders.
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Choline alfoscerate may also help boost production of human growth hormone in the elderly. While the production of human growth hormone in the brain doesn't typically decline with age, its release into the body can decline significantly. Choline alfoscerate can help stimulate the release of human growth hormone in the brains of older patients. Higher levels of HGH release can help keep elderly patients physically strong and healthy.
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Pays: | China |
N ° de modèle: | Alpha GPC 99% |
Prix FOB: | 1 ~ 400 / Kilogram ( Negotiable ) Obtenir le dernier prix |
Localité: | China |
Prix de commande minimale: | 1 per Kilogram |
Commande minimale: | 1 Gram |
Packaging Detail: | 25kg/drum |
Heure de livraison: | 15 days after payment |
Capacité de Fournir: | 30 Metric Ton per Month |
Payment Type: | T/T, L/C, Western Union |
Groupe de produits : | Nutrition supplement |