Description
The ELISA HBsAg reagent kit is designed for detection of surface
antigen of Hepatitis B virus (HBsAg) in human blood serum (plasma)
by applying ELISA technique. The ELISA HBsAg reagent kit allows to
detected mutant forms of Hepatitis B virus.
In a clinical laboratory analysis of various forms of viral
hepatitis B (HBV), a following number of serological markers of
this disease are determined: structural antigens (HBsAg and HBeAg),
as well as specific antibodies of the IgM and IgG classes to HBcore
antigen and IgG antibodies to HBs and HBe antigens.
HBsAg is a main marker of HBV infection, a structural protein
responsible for the adsorption of the virus on hepatocytes. It
appears in the blood as a first marker after **5 weeks from the
moment of infection until the onset of clinical symptoms and can be
detected during acute hepatitis for several months at fairly high
concentrations. In case of a favorable course of disease HBsAg
disappears withing **6 months after infection contamination. If it
does not happen, a chronic hepatitis is diagnosed.
The HBsAg concentration in the serum (plasma) of patients diagnosed
Hepatitis B virus varies in a wide range - from nanograms to
hundreds of micrograms per milliliter. HBsAg elimination from the
bloodstream is considered as a main criteria of patient
recovery.
ELISA is the most common and highly sensitive of diagnostic methods
among laboratory methods for determining HBsAg.
Scope - clinical laboratory diagnostics.
