FOB Price
Obtenir le dernier prix( Negotiable )
|Minimum Order
Localité:
-
Prix de commande minimale:
-
Commande minimale:
-
Packaging Detail:
PP Bottle
Delivery Time:
15days
Supplying Ability:
-
Payment Type:
T/T, PayPal
China
Personne àcontacter hu
zhangyang road, pudong district,, Shanghai, Shanghai
Product name: GHK-Cu(1:1)
CAS NO.: *********5
Sequence: Gly-His-Lys.Cu2+
M.W: **2.*2
M.F.: C*4H*2CuN6O4
Description: The human peptide GHK-Cu was isolated in ***3 by
Pickart as an activity in human albumin that caused old human liver
tissue to synthesize proteins like younger tissue. Subsequent
studies established this activity as a tripeptide with an amino
acid sequence glycyl-L-histidyl-L-lysine with a strong affinity for
copper that readily formed the complex GHK-Cu. It was proposed that
GHK-Cu functions as a complex with copper 2+. Pickart et al. have
established that GHK-Cu accelerates wound healing and contraction,
improves the take of transplanted skin, and also possesses
antiinflammatory actions.Subsequent studies directed by Borel and
Maquart et al. demonstrated that GHK-Cu at a very low, nontoxic
concentration (**0 nanomolar) stimulated both synthesis and
breakdown of collagen and glycosaminoglycans. GHK modulated an
activity of both metalloproteinases and their inhibitors (TIMP*1
and TIMP*2), acting as a main regulator of wound healing and skin
remodeling processes. GHK-Cu stimulated collagen, dermatan sulfate,
chondroitin sulfate, and a small proteoglycan, decorin. In ***1
McCormack et al. established that GHK-Cu restored replicative
vitality to fibroblasts from patients after anticancer radiation
therapy that damages cellular DNA.Wound healing activity of GHK-Cu
was confirmed in animal experiments. GHK-Cu accelerated wound
healing and increased blood vessel formation and the level of
antioxidant enzymes in rabbits. This molecule also induced systemic
wound healing in rats, mice, and pigs. It improved the healing of
diabetic and ischemic wounds in rats, decreasing the level of
TNF-alpha and stimulating collagen synthesis. It also facilitated
healing of pad wounds in dogs. Such well-documented skin
regeneration activity prompted widespread use of GHK in antiaging
cosmetic products.Recently, GHK-Cu has been gaining publicity as a
prospective therapeutic agent for chronic obstructive pulmonary
disease (COPD), skin inflammation, and metastatic colon cancer. It
has been established that it is capable of up- and downregulating
at least 4,**0 genes in the human genome, essentially resetting DNA
back to a healthier state. These studies shed new light on the skin
remodeling activity of the GHK-Cu peptide.
Format: blue powder or 1% solution.
​Package: 1Gram, *0Gram, **0Gram, 1KG(1% solution)
