Description

Grape Seed Extract

Product Name:Grape Seed Extract

Latin Name:Vitis vinifera L.

Parts Used:Seeds & skin

Appearance:Red brown fine powder

Active Ingredients:Proanthocyanidins (monomers, oligomers, polymers)

Specification:Proanthocyanidin *5%, polyphenol *5%      

Test Method:UV

Molecular Formula: C*0H*6O*2

Molecular Weight: **8.*3

CAS No.:*********1

Solubility: Partly soluble in water.

Appearance: Brownish-red powder, with slight oder,taste with a litter bitter.

Introduction of Grape Seed Extract

Grape Seed (skin) extract is an extract from the seed (skin)s of grapes. The seed (skin) s left over from the production of wine or juice are harvested, ground and extracted. They have a high content of compounds known as OPCs (oligomeric proanthocyanidins). Since French researcher, Dr. Jack Masquelier isolated OPCs from peanut skin in ***7, OPCs is found in many plants and has been declared to be a potent antioxidant of non-toxic, non-mutagenic, non-carcinogenic, and free of side effects according to a review of numerous researches.

Function:

The antioxidant capacity of Grape Seed (skin) Extract comes from proanthocyanidins (oligomeric proanthocyanidins) (OPCs). With an antioxidant power *0 times stronger than Vitamin C and *0 times stronger than Vitamin E, OPCs is known as a powerful antioxidant to neutralize free radicals, which play a major role in degenerative diseases, cardiovascular diseases, impaired vision, sun damage and premature aging.

1. Cardiovascular Diseases

Researches have assured that OPCs helps strengthen capillaries, arteries and veins, which endows it several important clinical applications. OPCs appear to stabilize the walls of blood vessels, reduce inflammation, and generally support tissues containing collagen and elastin.

1). Atherosclerosis:

It has been proved that the oxidation of LDL plays an important role in atherosclerosis. By its excellent antioxidant activity, OPCs eliminates damages that free radicals, as well as collagenase and elastinase do to the arteries, thus prevents or reverses atherosclerosis. Animal evidence suggested that OPCs could slow or reverse atherosclerosis.

2). Venous Insufficiency (Varicose Veins)

Varicose Veins refers to the situation when blood pools in the legs, causing pain, heaviness, swelling, fatigue, and unsightly visible veins. By strengthening capillary and reduce capillary osmosis, OPCs can relieve the pain and swelling of venous insufficiency. [8,9,*0] For the same reason, OPCs is recommended as a treatment for hemorrhoids as well. There is also some evidence that OPCs can be useful for the swelling that often follows injuries or surgery. [*1,*2,*3] OPCs appear to speed the disappearance of swelling, by strengthening damaged blood and lymph vessels that are leaking fluid.

A double-blind placebo-controlled study of *2 subjects found that OPCs, taken at a dose of **0 mg 3 times daily, significantly improved major symptoms, including heaviness, swelling, and leg discomfort. [*1] Over a period of 1 month, *5% of the participants treated with OPCs improved substantially. Another placebo-controlled study that enrolled **4 individuals with varicose veins also found that treatment with OPCs produced results superior to those of placebo.

3). Retinopathy/Vision Improvement

The capacity of OPCs in strengthening capillary and reduce capillary osmosis is effective for patients suffering from stroke and retinopathy. OPCs has been proved to improve retinopathy caused by diabetics, atherosclerosis, inflammation and aging. It has also been reported that OPCs can speed vision recovery after strong light, and improve vision acuity of those who suffer from eye fatigue because of long-time computer using.

A *-week, controlled (but not blinded) study evaluated the ability of grape seed (skin) OPCs to improve night vision in normal subjects. In this trial of **0 healthy volunteers, those who received **0 mg per day of OPCs showed improvements in night vision and glare recovery as compared to untreated subjects.

2. Aging/Alzheimer Disease

Because OPCs can easily pass the Blood-Brain Barrier, it can effectively inhibit the damage that free radicals do to the brain organism, so that Alzheimer Disease is prevented and reversed.

3. Skin Care

Because of its antioxidant activity, OPCs is thought to prevent the skin from excessive ultraviolet radiation and free radicals. Considerable evidences indicate that OPCs protects and strengthens collagen and elastin of the skin, so that wrinkle is prevented and elasticity of the skin is kept. OPCs in cream form are a popular treatment for aging skin, on the theory that by repairing elastin and collagen they will return skin to a more youthful appearance.

4.Anti-cancer, Anti-inflammation and Anti- allergic Activity

Since free radicals play a vital role in tumor formation, OPCs is reasonably used for its anti-cancer activity. Also for its inhibition of inflammatory factors such as PG, *-HT and Leukotriene, as well as selective binding to connective tissue of the joints to relieve pain and swelling, OPCs is helpful for kinds of arthritis. The anti-allergic activity of OPCs is thought to be the result of anti-histamine. Compared with other anti-allergic drugs, OPCs has the same efficacy and does not have the same side effects such as drowsiness.

Dosage:

For use as a general antioxidant much as you might use vitamin E or vitamin C, *0 mg of OPCs daily are sufficient. A higher dosage of **0 to **0 mg daily is generally used for treating specific diseases such as varicose veins.

Safety:

OPCs have been extensively tested for safety and are generally considered to be essentially nontoxic. Side effects are rare, but when they do occur they are limited to occasional allergic reactions and mild digestive distress. However, maximum safe dosages for young children, pregnant or nursing women, or those with severe liver or kidney disease have not been established.

OPCs may have some anticoagulant properties when taken in high doses, and should be used only under medical supervision by individuals on blood-thinner drugs. When taking Coumadin (warfarin), heparin, Trental (pentoxifylline), or aspirin, high doses of OPCs might cause a risk of excessive bleeding.

Chemistry:

This Product is composed of procyanidolic oligomers (OPCs).

Applications of Grape Seed Extract

1. Applied in food field, it\'s added into cake and cheese as nutrition exhanancer and inartificial preservative;

2. Applied in health products field, it\'s made into capsule,and it has already become one of the top ten salable natural plant extact products and owns the reputation of "natural health care product" and "orally cosmetics" in America;

3. Applied in pharmaceutical field, it is aslo used to treat cardiovascular disease;

4. Applied in cosmetic field, it\'s the main efficacy factor of toning lotion or cream. It has the efficacy of refirming, crease resisting and freckle curing, it can make skin smooth, exquisite and be full of flexibility.

[Package]

1KG : Packed in  Aluminum foil bag with pharma-grade polybags;

5KG : Packed in Aluminum foil bag with two pharma-grade polybags; or drum with pharma-grade polybag. Drum size:*0**0CM. Drum Weight:1.5KG

*0KG: Packed in  Aluminum foil bag with two pharma-grade polybags;

*5KG: Packed in HDPE drums/ Hardboard cartons with pharma-grade polybag.

Carton size:D*8 CM * H*2CM. Drum gross weight:2.8kgs

[Minimum quantity-MOQ]

1kg will be welcomed as the sample, but the less you buy, more expensive the price and transportation fees will be.

[Transport and Payment]

1. Small package send by EMS, UPS, FedEx, DHL, etc.

2. Cargo send by Air or By Sea is all available when the purchasing weight is allowed

3. Delivery time about 7 working days By Air, *0 days By sea.

4. Payment available for T/T, Paypal, etc., Paypal with little money for samples will be the one we suggested.

[Delivery cost]

The price of the transportation fees need to consider the transportation ways and fees.

[About Manufacturer Kang Biotech]

History: “Hunan Kang Biotech” is a subsidiary of “Hunan Kang Pharmaceutical Group”, which engaged in the natural ingredients\' research & development (R & D), production and selling. Providing the high-quality natural materials for manufacturers and enterprises of botanical drug, health food, beverage, cosmetic etc.

Certification: Our company is equipped with UV/HPLC/GC/AA and other modern analyzing instruments to assure high quality. Our factory have passed GMP in Aug.*0.***0, Certificate No.:J***1

Factory: Hunan Kang Biotech’s factory covers an area of **0 Acres, and the production workshop is designed according to GMP standard.

[Why Chose Kang Biotech]

1)Free sample(****0g or enough to detection) and Unconditional assume respond

2)**0% Natural product, without any synthesize ingredient

3)Manufacturer direct supply, provide OEM, R&D service

4)GMPs,Gsp

5)Leading plant extract manufacturer in China