Description
Toxicology: A single oral dose toxicity study in
rats administered Glucosol 5 g/kg showed no marked pathological
findings.But toxicologic information regarding use in humans is
lacking.
Dosage: Numerous commercial formulations are
available, including tablets, capsules, hypoglycemic food products,
and cosmetics. Most formulations are available in capsule form
containing *8% corosolic acid extracted from L. speciosa . The
manufacturer suggested dosage is 1 softgel by mouth *0 minutes
before morning and evening meals. Softgel products are marketed for
noninsulin dependent type 2 diabetic patients.
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Application:
1. Be
available in American as food additive.
2. Be
used in dietary supplements as a glucose-lowering agent and insulin
mimetic.
Contraindications:
1.
Avoid use with hypersensitivity to any of the plant sources of
corosolic acid.
2.
Avoid use in the pregnancy the lactation.
Corosolic Acid Interactions:Counsel patients with
diabetes or those taking antidiabetic medications about potential
additive effects if they are self-medicating with any oral
corosolic dietary supplement.
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What
is Banaba Leaf extract?
Banaba leaf extract contains a triterpenoid compound known as
corosolic acid which has actions in stimulating glucose transport
into cells. As such, banaba plays a role in regulating levels of
blood sugar and insulin in the blood. For some people, fluctuations
in blood sugar and insulin are related to appetite, hunger and
various food cravings particularly craving for carbohydrates such
as bread and sweets. By keeping blood sugar and insulin levels in
check, banaba may be an effective supplement for promoting weight
loss in certain individuals Banaba is a medicinal plant that grows
in India, Southeast Asia and the Philippines. Traditional uses
include brewing tea from the leaves as a treatment for diabetes and
hyperglycemia (elevated blood sugar). The hypoglycemic (blood sugar
lowering) effect of banaba leaf extract is similar to that of
insulin which induces glucose transport from the blood into body
cells.
The blood sugar regulating properties of banaba have been
demonstrated in cell culture, animal and human studies. In isolated
cells, the active ingredient in banaba extract, corosolic acid, is
known to stimulate glucose uptake. In diabetic mice, rats and
rabbits, banaba feeding reduces elevated blood sugar and insulin
levels to normal. In humans with type II diabetes, banaba extract,
at a dose of ****8mg per day for **8 weeks, has been shown to be
effective in reducing blood sugar levels (5%**0% reduction) and
maintaining tighter control of blood sugar fluctuations. An
interesting (side-effect) of tighter control of blood sugar and
insulin levels is a significant tendency of banaba to promote
weight loss (an average of **4 lbs. per month) without significant
dietary alterations. It is likely that modulation of glucose and
insulin levels reduces total caloric intake somewhat and encourages
moderate weight loss.
Where will be Banaba Leaf extract used to?
* Antidiabetic
*
Anti-inflammatory
*
Antiproliferative
*
Protein kinase C inhibition activity
* Help
maintain low blood pressure and normal kidney function, preventing
damage to blood vessels and kidneys
* Help
control appetite and cravings, helps promote weight
loss
*
Reduce the tolerance of P. aeruginosa biofilm bacteria to
antibiotics
*
Deliver a strong antioxidant activity to scavenge free radicals and
to prevent cell membrane lipid peroxidation
* May
help with reaction to stress.
* May help maintain cortisol levels
within the normal range.
