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Personne àcontacter Mr. Khasan
77 H.Abdullaev, Tashkent
Desoxypeganine hydrochioride is chloride salt of the alkaloid desoxypeganine from the Peganum harmala plant. Desoxypeganine hydrochioride is an inhibitor of cholinesterase. Its anticholinesterase effect is reversible. It also has a direct stimulative influence on cholinoreceptors. As the fermentative activity of cholinesterase is depressed and the cholinoreceptors sensitiveness is raised, the transmission of nervous impulses in the cholinoreceptive synapses occurs easily. The drug restore the neuromuscular conductivity, broken by the antidepolarizing relaxants, increases the vitality of the smooth musculature and intensifies a salivation. Desoxypeganine hydrochioride is prescribed to the patients suffering from the damaged peripheral nervous system of various etiology; it is effective for diseases, accompanied by the affections of the front horns of the spinal cord; it is used for the treatment of the broken brain blood circulation consequences; it is also effective for myasthenia and myopathy-like syndromes of various genesis. For the last few years Desoxypeganine is used as drug against smoking. Desoxypeganine hydrochioride is the same as Galanthamine hydrobromide, Neostigmine methylsulfate and Eserinum by principal pharmacological properties, but it differs by exerting high anticholinesterase activity and lower toxicity. Desoxypeganine in 6 times is more effective than Neostigmine methylsulfate. The drug has got a good absorption ability by hypodermic and Intramuscular injection; it easily penetrates through the blood-brain barrier and is excreted by kidneys in the form of the weak active oxidized products. Produced in the form of pure substance, tablets (0,*5 g) and in 2 ml ampules of 1% water solution. Additional information Approval of Ministry of Health of the USSR N**7 (June *6,***9) for practical use in all Republics of former USSR.
