Cytisine API (substance) By Institute of the Chemistry of Plant Substances, Uzbekistan
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Cytisine API (substance)

Cytisine API (substance)

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Personne à contacter Mr. Khasan

77 H.Abdullaev, Tashkent

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Description

Cytisine - respiratory analeptic. Composition cytisine is quinolizidine alkaloid present in the seeds of thermopsis lancefljata. Cytisine is related to compounds of "ganglionic activity". The alkaloid are used as respiratory analeptic. For the last few years cytisine is used as drug destined for aversion from smoking. Cytisine invokes irritation at ganglia of vegetative nervous system and related organs: Chromaffin tissue of suprarenals and carotid bodies. Intrinsic to cytisine respiration activation is called by it reflectory stimulation of respiratory center, activated by impulsation from carotid bodies. Simultaneously the drug activates sympathetic nodes and paranephros and by this way increases arterial pressure. At reflectory respiratory block (at surgical operations; traumas and etc. ) it can be used as respiratory analeptic. Its pressor effect permits usage of the cytisine at shock and collaptic states; at respiratory and circulatory depression of patients with infection diseases and etc. The drug is contraindicated (in view of its pressor activity) for the patients with obvious atherosclerosis and hypertension, bleedings, edema of the lungs. Cytisin available in substance and also under the trade name cytitonum used as 0,*5% *1,0 ml solution in ampoules. Clinical trials have been carried out in clinics of Russia, Ukraine and uzbekistan. Spc document *********1 (june *3,***1) of the pharmacological committee of Russia.

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