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Personne àcontacter Peng
| Item Name | Meropenem trihydrate |
| CAS NO | **********7 |
| Appearance | White Powder |
| package | Aluminum Bag;Drums |
| Purity | *9% |
| Storage | Store in a tightly closed container and cool dry place where the temperature stays below *0ºC |
Function
Meropenem is bactericidal except against Listeria monocytogenes where it is bacteriostatic. It inhibits bacterial wall synthesis like other beta-lactam antibiotics. In contrast to other beta-lactams, it is highly resistant to degradation by beta-lactamases or cephalosporinases. Resistance generally arises due to mutations in penicillin binding proteins, production of metallo-beta-lactamases, or resistance to diffusion across the bacterial outer membrane. Unlike imipenem, it is stable to dehydropeptidase*1 and can therefore be given without cilastatin.
Application
The spectrum of action includes many Grampositive and Gram negative bacteria (including Pseudomonas) and anaerobic bacteria. The overall spectrum is similar to that of imipenem , although meropenem is more active against Enterobacteriaceae and less active against Gram-positive bacteria. It is also very resistant to extended-spectrum beta lactamases but may be more susceptible to metallo-beta-lactamases. Meropenem is frequently given in the treatment of febrile neutropenia . This condition frequently occurs in patients with hematological malignancies and cancer patients receiving anticancer drugs that cause bone marrow suppression. It is approved for complicated skin and skin structure infections, complicated intra-abdominal infections and bacterial meningitis.
|
Item
|
Specification
|
|
Specific
rotation
|
+*9.5
to +*1.5°
|
|
State of
solution(transmittance)
|
Clear
*8.0%
min.
|
|
Chloride[Cl]
|
0.**0%
max.
|
|
Ammonium
[NH4]
|
0.*2%
max.
|
|
Sulfate[SO4]
|
0.**0%
max
|
|
Iron[Fe]
|
*0ppm
max.
|
|
Heavy metals
[Pb]
|
*0ppm
max
|
|
Arsenic[As2O3]
|
1ppm
max
|
|
Other amino
acids
|
Chromatographically
not detectable
|
|
Loss on
drying
|
0.*0%
max.
|
|
Residue on
ignition[sulfated]
|
0.*0%
max.
|
|
Assay
|
*9.0%
min
|
| Pays: | Others1 |
| N ° de modèle: | CAA-OC-509 |
| Prix FOB: | Obtenir le dernier prix |
| Localité: | - |
| Prix de commande minimale: | - |
| Commande minimale: | - |
| Packaging Detail: | - |
| Heure de livraison: | - |
| Capacité de Fournir: | - |
| Payment Type: | - |
| Groupe de produits : | - |
