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| Product Name: | Trichlormethiazide |
| CAS: | *******5 |
| MF: | C8H8Cl3N3O4S2 |
| MW: | **0.*6 |
| EINECS: | ********8 |
| Chemical Properties | Trichlormethiazide occurs as a white or practically white, crystalline powder and may have a slight characteristic odor. |
| Uses | diuretic, antihypertensive |
| Uses |
Trichlormethiazide is a
diuretic and anti-hypertensive agent from the benzothiadiazide
class which is used in veterinary medicine in cattle, sheep, goats,
pigs and horses, at the following therapeutic regimen: a single
intramuscular dose of 0.4 mg/kg bw followed by two oral doses of
0.8 mg/kg bw given *2 and *6 hours after the first
administration. Trichlormethiazide is also used in humans in the United States as a diuretic and anti-hypertensive substance but not in the European Union. The usual dose is 2 to 4 mg twice a day (i.e. approximately 0.**3 to 0.**6 mg/kg bw/day). |
| Manufacturing Process | A mixture of 5.7 grams (0.*2 mol) of *-chloro*2,*-disulfamylaniline and 4.9 grams (0.*4 mol) of dichloroacetaldehyde in *5 ml of dimethyl formamide was heated at the boiling temperature and under reflux for *0 minutes. The reaction mixture was thereafter poured into a mixture of ice and water to precipitate the desired *-chloro**-sulfamyl**-dichloromethyl*3,*-dihydro- 1,2,*-benzothiadiazine*1,*-dioxide as a crystalline solid melting at **0° to **0°C with decomposition. |
| Therapeutic Function | Diuretic |
| Pays: | China |
| N ° de modèle: | - |
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