Prix FOB
Obtenir le dernier prix( Negotiable )
|1 Milligram Minimum Order
Pays:
China
N ° de modèle:
TL-509
Prix FOB:
( Negotiable ) Obtenir le dernier prix
Localité:
Beijing China
Prix de commande minimale:
-
Commande minimale:
1 Milligram
Packaging Detail:
-
Heure de livraison:
-
Capacité de Fournir:
-
Payment Type:
T/T
Groupe de produits :
China
Personne àcontacter Key
Building 13, No. 50 Huatuo Road, Daxing District, Beijing, Beijing, Beijing
Recombinant Human IL**1
Protein
Catalog Number:
TL***9
Product name
Generic
names:Â Recombinant Human IL**1 Protein
Gene Name
Synonym:Â CVID*1, IL**1, Za*1
Product information
Construction:Â A DNA sequence encoding the extracellular
domain of human IL**1 (Q9HBE**1)) was expressed with the C-terminal
fused Fc region of human IgG1.
Source:Â Human
ExpressionHost:Â Â CHO
cells
QC Testing
Purity:Â > *5
% as determined by SDS-PAGE
Bio
Activity:Â Determined by its ability to stimulate the
proliferation of human ANBL*6 cells. The
expected ED *0 is ≤ 0.5
ng/ml, corresponding to a specific activity of ≥ 2
x*0^6units/mg.
Endotoxin: < 0.*1 EU per μg of the protein as determined
by the LAL method.
Molecular
Mass:Â The
recombinant human IL**1 consists of **6 amino acids and predicts a
molecular mass of *1
Kda.
Formulation:Â Lyophilized from sterile PBS, pH 7.4.
Normally 6 % - 8 % trehalose, mannitol are added as protectants
before lyophilization.
Stability &
Storage:Â Samples are stable for up to *4 months from date
of receipt at 4 ℃ . Recommend to aliquot the protein into smaller
quantities for optimal storage. Avoid repeated freeze-thaw
cycles.
Background
IL**1 is a pleiotropic cytokine
produced by CD4+ T cells in response to antigenic stimulation. Its
action generally
enhances antigen-specific responses
of immune cells. The biological effects of IL**1 include: inducing
the
differentiation of T-cell-stimulated
B-cells into plasma cells and memory B-cells; the stimulation of
IgG production in
conjunction with IL*4; and the
induction of apoptotic effects in nave B-cells and stimulated
B-cells in the absence of
T-cell signaling. Additionally,
IL**1 promotes the anti-tumor activity of CD8+ T-cells and NK
cells. IL**1 exerts its
effect through binding to a specific
type I cytokine receptor, IL**1R, which also contains the γ chain
(γc) found in other
cytokine receptors, including IL*2,
IL*4, IL*7, IL*9 and IL**5. The IL**1/IL**1R interaction triggers a
cascade of events,
which includes activation of the
tyrosine kinases JAK1 and JAK3, followed by activation of the
transcription factors
STAT1 and
STAT3.
References
1. Coquet JM, et al. (***7) IL**1 is
produced by NKT cells and modulates NKT cell activation and
cytokine production.
BEIJING T&L BIOLOGICAL
TECHNOLOGY CO.,LTD. For research use only.J Immunol.
**8(5):******4.
2. Wei L, et al. (***7) IL**1 is
produced by Th*7 cells and drives IL**7 production in a
STAT*-dependent manner. J
Biol Chem. **2(*8):*******0. G&W
Biotechnologie GmbH For research use only.
3. Parrish-Novak J, et al. (***2)
Interleukin**1 and the IL**1 receptor: novel effectors of NK and T
cell responses. J
Leukoc Biol.
*2(5):*****3.
4 .Kuchen S, et al. (***7) Essential
role of IL**1 in B cell activation, expansion, and plasma cell
generation during
CD4+ T cell-B cell collaboration. J
Immunol. **9(9):******6.
Â
Trial
dosage: A customer can apply for up to five samples a year (the
actual trial dosage is determined by telephone or email
communication).
Scope of use: Samples are limited
to testing and research purposes.
Cost: Free for samples, customer
is responsible for shipping and handling charges, reference cost is
$*0 in the US, €*0 in the EU, and $*0 in other
countries.
How to apply: You can apply by
telephone or by email (the email application should specify the
sample name, item number, contact person, telephone number,
consignee address, etc.).
| Pays: | China |
| N ° de modèle: | TL-509 |
| Prix FOB: | ( Negotiable ) Obtenir le dernier prix |
| Localité: | Beijing China |
| Prix de commande minimale: | - |
| Commande minimale: | 1 Milligram |
| Packaging Detail: | - |
| Heure de livraison: | - |
| Capacité de Fournir: | - |
| Payment Type: | T/T |
| Groupe de produits : | Recombinant Protein |
